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Center for Cognitive Medicine Regions of Interest Map Guide


Click here to download our current ROIs in AFNI file format!

ROIs are defined in Talairach space. Voxels along the longitudinal fissure are designated as R£0, L³1, where x=0 is allotted to the R-side of the brain.  R and L ROI’s for each region are symmetric sagittally, with equal volumes.  ROIs are defined anatomically or functionally (by plotting and encompassing mean and peak activation coordinates for this region from a number of studies) and drawn from a merged structural image of 15 healthy subjects.

Region

Hemisphere

     R         L

Description

Superior Precentral Sulcus ( SupPCS )

1

2

Defined anatomically

Ant: extends 7-9 mm anterior to the juncture between the Medial Frontal Gyrus and the Precentral Sulcus

Post: extending to, but not including voxels contiguous with the Central Sulcus

Sup: to edge of cerebral cortex (to z=71)

Inf : contiguous with InfPCS (to z=30)

Med: extends 2 voxels beyond extent of superior precentral sulcus

Lat: to edge of cerebral cortex

Inferior Precentral Sulcus ( InfPCS )

3

4

Defined anatomically

Ant: extends 5 mm anterior to inferior precentral sulcus (to y=-14)

Post: extends 5 mm posterior to inferior precentral sulcus (to y=3)

Sup: contiguous with SupPCS

Inf : contiguous with Insula (except where lateral edges extending beyond insula )

Med: inferiorly contigous with Insula , superiorly extends to gray/white border

Lat: to edge of cerebral cortex

Frontal eye fields (FEF)

FEF= SupPCS + InfPCS

Pre-Supplemental Eye Field ( PreSEF )

5

6

Ant: includes dorsomedial cortex along the longitudinal fissure immediately anterior to the SEF, extending rostrally to y= -26

Post: contiguous with SEF (to y=-7)

Sup: to edge of cerebral cortex (z=72)

Inf : contiguous with cingulate cortex, not including voxels within the cingulate sulcus

Med: a midline structure crossing the longitudinal fissure

Lat: to gray/white junction (y= ±12)

Supplemental Eye Field (SEF)

7

8

Ant: includes the dorsomedial cortex along the longitudinal fissure immediately posterior to PreSEF (y=-6, a coronal plane 5 mm anterior to the anterior commissure )

Post: at coronal plane anterior the paracentral sulcus (y=15)

Sup: to edge of cerebral cortex (z=73)

Inf : contiguous with cingulate cortex, not including voxels within the cingulate sulcus

Med: a midline structure crossing the longitudinal fissure

Lat: to gray/white junction (y= ±12)

Middle Frontal Gyrus (MFG)

9

10

Defined anatomically

Ant: extent of cerebral cortex within 5 voxels of superior and inferior frontal sulci . Excludes active voxels arising from the frontal pole on the longitudinal fissure anterior to pre-SEF

Post: extent of cerebral cortex within 5 voxels of superior and inferior frontal sulci .

Sup: to edge of cerebral cortex

Inf : extent of cerebral cortex including superior and inferior frontal sulci

Med: to gray-white junction

Lat: to edge of cerebral cortex

Insula

11

12

Defined anatomically

Ant, Post, Sup, Inf : includes cerebral cortex within 3 voxels of long and short insular gyri and circular sulcus

Med: 3 voxels lateral to putamen (non-contiguous)

Lat: a portion contiguous with InfPCS

IntraParietal Sulcus (IPS)

13

14

Defined anatomically to include the intraparietal sulcus proper, all branches, and the immediately adjacent cortical surface.

Ant: contiguous with but not including the central sulcus

Post, Sup, Lat: to edge of cerebral cortex

Posterior-inferior: to parieto-occipital sulcus

Inf : z=29

Med: contiguous with precuneus region (x= ±19)

Precuneus

15

16

Defined anatomically.

Ant: 5 mm posterior to the cingulate region

Post, Sup: to edge of cerebral cortex

Posterioinferior : to parieto -occipital sulcus

Inf : z=29

Lat: contiguous with intraparietal sulcus region (x= ±20)

Cingulate

Defined anatomically to include all cortex lying between the corpus callosum and the cingulate sulcus

Anterior Cingulate ( AntCing )

17

18

Defined anatomically, except posterior border with motor cingulate region which was defined functionally.

Ant : to cingulated sulcus (y= -52)

Post: contiguous with motor cingulate region (y= -16)

Sup: to cingulate sulcus (z=43 in midline), posterior portion of region contiguous with PreSEF region

Inf : ant portion contiguous with Sub- Genu cingulated region (z=10), post portion contiguous with corpus callosum

Med: a midline structure

Lat: to gray-white junction (x= ±18 at greatest width)

Posterior Cingulate ( PostCing )

27

28

Defined anatomically to include posterior one-half of cingulate gyrus

Ant: coronal plan one-half the distance between anterior and posterior commissures ( Paus , 1996) (y=12)

Post: to cingulate sulcus (y=52)

Sup: to cingulate sulcus (z=44 at most superior point)

Inf : to edge of cerebral cortex, not including any area within nearby cerebellum (z=10)

Med: a midline structure

Lat: to gray-white junction (x=±18 at greatest width)

Cingulate Motor Area

49

50

Defined functionally by Paus , 1996 for division between anterior and posterior cingulate and Picard and Strick , 1996; 2001 for motor division of cingulate .

Ant: contiguous with anterior cingulate region (y= -15)

Post: contiguous with posterior cingulate (y=11)

Sup: to cingulate sulcus (z=44 at most superior point)

Inf : to corpus callosum

Med: a midline structure

Lat: to gray-white junction (x=±18 at greatest width)

Sub- Genu Cingulate

57

58

Defined anatomically.

Ant: to cingulate sulcus (y=-52)

Post: to corpus callosum (y=20)

Sup: contiguous with anterior cingulate region and inferior to the genu (z=9)

Inf : to cingulate sulcus (z= -8)

Med: a midline structure

Lat: x= ± 10 mm at greatest width

Thalamus

21

22

Defined anatomically to include thalamic regions without including adjacent white matter or ventricular areas.

Ant: portion contiguous with caudate, portion contiguous with ventricle, portion contiguous with white matter

Post, Sup, Med: contiguous with ventricle

Inf , Lat: to gray-white junction

Lateral Cerebellum ( LatCer )

23

24

Defined anatomically. Includes both Anterior and Posterior regions of LatCer . Due to individual variation, care was taken to avoid any overlap of visual cortex with LatCer ROI, leaving a constant space of 7 mm unmapped between cerebellum and visual cortex. Vermis , dentate nucleus, other cerebellum nuclei, and prominent white matter projections were excluded from this ROI.

SupraMarginal Gyrus (SMG)

25

26

Defined anatomically on merged map of 15 control subjects with help of brain atlas ( Duvernoy HM, 1991)

Primary Visual Cortex (V1/V2)

29

30

Defined anatomically & functionally b : regions directly above and below the calcarine sulcus ;

Dentate Gyrus

31

32

Defined anatomically

Colliculi

33

34

Defined anatomically

Medial Temporal Gyrus (MT)

35

36

Defined functionally. c Bounded posteromedially in part by V3 and medially by white matter visual projections.

Caudate

43

44

Defined anatomically to include the head of the caudate region without including adjacent white matter or ventricular areas.

Ant, Sup, Med: to ventricular region

Post: contiguous with portion of thalamus and white matter

Inf , Lat: to gray-white junction

Putamen

45

46

Defined anatomically to include the putamen region without including adjacent white matter.

Ant, Post, Sup, Lat: to gray-white junction

Med: anteriorly to gray-white junction, posteriorly contiguous with globus pallidus region

Inf : to edge of cerebral cortex

Globus Pallidus

47

48

Defined anatomically to include globus pallidus region without including adjacent white matter.

Lat: contiguous with putamen region

Ant, Post, Sup, Inf , Med: to gray-white junction

Cerebellar Vermis

(divided A-P, not R-L)

51 (ant)

52 (post)

Defined anatomically with primary fissure dividing anterior and posterior, extending ± 4 mm from the mid- sagittal section, thus not included in LatCer

V3

53

54

Defined functionally a

Posterior Superior Temporal Sulcus ( pSTS )

55

56

Defined anatomically:

Post :MT

Ant :up to and including STS

Med: visual projections/white matter tracts, Lat border=all cortex, Sup : Supramarginal gyrus and IPS or projection of Sylvian fissure

 

Ant = anterior; Post = posterior; Sup = superior; Inf = inferior; Med = medial; Lat = lateral

For questions regarding these ROIs, please contact Sarah Keedy (skeedy@psych.uic.edu) or John Sweeney (jsweeney@uic.edu)

 


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