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Pauline
M. Maki, Ph.D. directs a comprehensive program of research on treatments
that influence the rate of cognitive aging. Her primary focus over the
last 8 years has been the effects of sex steroid hormones, including
estrogen, progesterone, and testosterone on age-related changes in
cognition and brain function. The program comprises a series of
observational studies and clinical intervention trials. She uses
neuropsychological and neuroimaging tools (i.e., positron emission
tomography and structural and functional magnetic resonance imaging) in to
study estrogen replacement, botanical treatments for menopausal symptoms,
testosterone supplementation, premature ovarian failure, menstrual cycle,
endogenous estrogens, hormone suppression, and SERMs.
Dr. Maki is a co-investigator in the Women’s Health Initiative Study
of Cognitive Aging, a 6-year randomized study of cognitive aging in a
large subsample (n = 2300) of women enrolled in the Randomized Hormone
Replacement Trial of the Women's Health Initiative. She is a
co-investigator on a parallel, randomized trial for the study Cognition in
the Study Tamoxifen and Raloxifene (Co-STAR) involving 1200 women, as well
as more than 10 other clinical trials examining hormone effects on
cognition and brain functioning.
Research Studies
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